Efficient Synthesis of Imidazole Derivatives: An Important Synthon for the Preparation of Biologically Active Compounds
نویسندگان
چکیده
Asghar DAVOOD, Eskandar ALIPOUR, Abbas SHAFIEE3,∗ Department of Medicinal Chemistry, Faculty of Pharmacy, Islamic Azad University, Tehran-IRAN Department of Organic Chemistry, Faculty of Chemistry, Islamic Azad University, Tehran-IRAN Department of Chemistry, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14174 IRAN e-mail: [email protected]
منابع مشابه
Sodium Bismuthate: An Efficient Catalyst for the One-pot Synthesis of Biologically Active Spiro[4H-pyran] Derivativesunder Solvent-free Conditions
An efficient sodium bismuthate (NaBiO3) synthesis of biologically active spiro[4H-pyran]derivatives has been accomplished via one-pot three-condensation of isatin/acenaphthequinone, malononitrile and different reagents including 1,3-dicrbonyl compounds, α-naphthol and 4-hydroxycumarin under solvent-free conditions. The notable advantages of the present procedure are: eco-friendly, environmental...
متن کاملDesign and Synthesis of New Imidazole Derivatives of Captopril
A new series of alkylthio imidazole analogues of captopril, an ACE inhibitor used in the treatment of hypertension, was designed and synthesized in order to obtain agents more active than captopril with less side effects. All the compounds thus prepared were purified and characterized by IR, NMR and Mass analytical instruments.
متن کاملDesign and Synthesis of New Imidazole Derivatives of Captopril
A new series of alkylthio imidazole analogues of captopril, an ACE inhibitor used in the treatment of hypertension, was designed and synthesized in order to obtain agents more active than captopril with less side effects. All the compounds thus prepared were purified and characterized by IR, NMR and Mass analytical instruments.
متن کاملApplication of Water for Synthesis of Cyclopentadienes via Multi-component Reactions of N-methyl imidazole
A water-accelerated multi-component synthesis of organic target molecules was used as a key method for the preparation of cyclopentadiene derivatives. The three-component condensation reactions of primary amines with alkyl propiolates in the presence of N-methylimidazole in water at room temperature were developed as efficient and clean green synthetic procedures for the high-yielding preparati...
متن کاملSolvent-free Biginelli Reaction Catalyzed to Synthesis of Biologically Active 3,4-dihydropyrimidin-2-(1H) –ones/thiones Derivatives
A convenient and highly efficient procedure for the synthesis of 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives via one-pot three-component Biginelli condensation of arylaldehydes,urea/thiourea and ethyl/methyl acetoacetate in the presence of Zn(SO4)2.7H2Oas anefficient, readily and inexpensive catalyst under solvent-free conditions have been studied. Thisprotocol ha...
متن کامل